Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational regulation of complement protein C2 expression by differential utilization of the 5'-untranslated region of mRNA.

The Journal of biological chemistry - 25 Apr 1990

Horiuchi T, Macon K J, Kidd V J, Volanakis J E

Abstract excerpt

A recently isolated cDNA for human complement protein C2, C2HL5-3, has an unusually long 5'-untranslated region (UTR) containing four open reading frames upstream of the authentic initiation codon. Here we report that deletion of the 5'-UTR of C2HL5-3 resulted in a 10-fold enhancement in the translational efficiency of C2 in transient eukaryotic cellular assays. Elimination of the open reading frames in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Share to Restriction Mapping

Share to RNA, Messenger

Source

Identifiers

PMID: 2324087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Translational regulation of complement protein C2 expression by differential utilization of the 5'-untranslated region of mRNA.PMID 2324087Read ↗

Murine complement C2 and factor B genomic and cDNA cloning reveals different mechanisms for multiple transcripts of C2 and B.Semantic proximity Read ↗

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.Semantic proximity Read ↗

CNP2 mRNA directs synthesis of both CNP1 and CNP2 polypeptides.Semantic proximity Read ↗

Translational efficiency of bovine pyruvate carboxylase 5' untranslated region messenger ribonucleic acid variants.Semantic proximity Read ↗

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.Semantic proximity Read ↗

Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region.Semantic proximity Read ↗

New Vascular Endothelial Growth Factor Isoform Generated by Internal Ribosome Entry Site-Driven CUG Translation InitiationSemantic proximity Read ↗

Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNASemantic proximity Read ↗

Production and interferon-γ-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MGSemantic proximity Read ↗

In vivo translational efficiency of different hepatitis C virus 5'-UTRs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.