Article
Translational regulation of complement protein C2 expression by differential utilization of the 5'-untranslated region of mRNA.
The Journal of biological chemistry - 25 Apr 1990
Horiuchi T, Macon K J, Kidd V J, Volanakis J E
Abstract excerpt
A recently isolated cDNA for human complement protein C2, C2HL5-3, has an unusually long 5'-untranslated region (UTR) containing four open reading frames upstream of the authentic initiation codon. Here we report that deletion of the 5'-UTR of C2HL5-3 resulted in a 10-fold enhancement in the translational efficiency of C2 in transient eukaryotic cellular assays. Elimination of the open reading frames in the...
Topics
- Base Sequence
- Cell Line
- Complement C2
- DNA
- Gene Expression Regulation
- Humans
- Liver
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Promoter Regions, Genetic