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Article

Low frequency of germline mutations in the RET proto‐oncogene in patients with apparently sporadic medullary thyroid carcinoma

1 Jul 1995

Abstract excerpt

BACKGROUND AND OBJECTIVES: Medullary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for MEN 2 is the RET proto-oncogene. Systematic analysis for...

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Identifiers

PMID: 7641404
DOI: 10.1111/j.1365-2265.1995.tb01903.x

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Related research

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Low frequency of germline mutations in the RET proto‐oncogene in patients with apparently sporadic medullary thyroid carcinomaPMID 7641404Read ↗

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RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center.Semantic proximity Read ↗

RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

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Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

No correlation between RET immunostaining and the codon 918 mutation in sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Twenty-Five Years Experience on RET Genetic Screening on Hereditary MTC: An Update on The Prevalence of Germline RET MutationsSemantic proximity Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)Semantic proximity Read ↗

Analysis ofRET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomasSemantic proximity Read ↗

Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

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