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Article

Analysis ofRET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomas

1 Aug 1995

Abstract excerpt

BACKGROUND: The distinction of sporadic from inherited medullary thyroid carcinomas (MTCs) is of clinical importance because of the differences in prognosis, and the need for family screening for genetic counseling required in the latter. Germline mutations in the RET protooncogene are associated with multiple endocrine neoplasia (MEN) type 2A, familial medullary thyroid carcinoma (FMTC), and MEN type 2B. Somatic...

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PMID: 8625130
DOI: 10.1002/1097-0142(19950801)76:3<479::aid-cncr2820760319>3.0.co;2-m

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