Article
Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.
The Journal of cell biology - 7 Apr 1997
Weaver V M, Petersen O W, Wang F, Larabell C A, Briand P, Damsky C, Bissell M J
Abstract excerpt
In a recently developed human breast cancer model, treatment of tumor cells in a 3-dimensional culture with inhibitory beta1-integrin antibody or its Fab fragments led to a striking morphological and functional reversion to a normal phenotype. A stimulatory beta1-integrin antibody proved to be in...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Basement Membrane
- Binding, Competitive
- Breast Neoplasms
- Cell Division
- Extracellular Matrix
- Female
- Fluorescent Antibody Technique
- Genotype
- Humans
- Immunoglobulin Fab Fragments
- Integrin beta1