Adhesion molecules in breast cancer: role of alpha 2 beta 1 integrin.

Abstract excerpt

An early event in the development of breast carcinomas is the loss of normal tissue architecture. In benign lesions and in situ tumours both luminal and myoepithelial cells are present, but in most invasive cancers the malignant cell has the phenotype of the luminal cell, and proliferates without contacting the myoepithelial cells or the basement membrane. The reduction in cell contacts is clearly crucial for the...

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