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Article

Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone.

International journal of molecular sciences - 27 Jun 2021

Moritz Milene N O, Merkel Alyssa R, Feldman Ean G, Selistre-de-Araujo Heloisa S, Rhoades Sterling Julie A

Abstract excerpt

Integrins participate in the pathogenesis and progression of tumors at many stages during the metastatic cascade. However, current evidence for the role of integrins in breast cancer progression is contradictory and seems to be dependent on tumor stage, differentiation status, and microenvironmental influences. While some studies suggest that loss of α2β1 enhances cancer metastasis, other studies suggest that...

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Identifiers

PMID: 34199096
DOI: 10.3390/ijms22136906
PMCID: PMC8269289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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