Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.

Journal of the National Cancer Institute - 2 Oct 2002

Wang Fei, Hansen Rhonda K, Radisky Derek, Yoneda Toshiyuki, Barcellos-Hoff Mary Helen, Petersen Ole W, Turley Eva A, Bissell Mina J

Abstract excerpt

BACKGROUND: We previously used a three-dimensional (3D) reconstituted basement membrane (rBM) assay to demonstrate that tumorigenic HMT-3522 T4-2 human breast cells can be induced to form morphologically normal structures ("reversion") by treatment with inhibitors of beta1 integrin, the epidermal growth factor receptor (EGFR), or mitogen-activated protein kinase (MAPK). We have now used this assay to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basement Membrane
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colony-Forming Units Assay

Share to Integrin beta1

Share to Mitogen-Activated Protein Kinases

Share to Monomeric GTP-Binding Proteins

Share to Neoplasms, Experimental

Share to Vimentin

Source

Open in PubMed Open full text

Identifiers

PMID: 12359858
DOI: 10.1093/jnci/94.19.1494
PMCID: PMC2975573

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.PMID 12359858Read ↗

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.Semantic proximity Read ↗

Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer.Semantic proximity Read ↗

Modeling breast acini in tissue culture for detection of malignant phenotype reversion to non-malignant phenotype.Semantic proximity Read ↗

β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and <i>In vivo</i>Semantic proximity Read ↗

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane cultureSemantic proximity Read ↗

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells.Semantic proximity Read ↗

A Human Breast Cell Model of Preinvasive to Invasive TransitionSemantic proximity Read ↗

Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.Semantic proximity Read ↗

'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin.Semantic proximity Read ↗

Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.Semantic proximity Read ↗

Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.Semantic proximity Read ↗

The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.