Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells.

doi:10.1016/0092-8674(90)90098-y

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Article

Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells.

Cell - 9 Mar 1990

Giancotti F G, Ruoslahti E

Abstract excerpt

We report here on gene transfer studies designed to investigate the function of the alpha 5 beta 1 integrin and its role in transformation. Transfection of the human alpha 5 and beta 1 cDNAs into transformed Chinese hamster ovary (CHO) cells followed by methotrexate-induced amplification yielded...

Topics

Animals
Cell Adhesion
Cell Division
Cell Line
Cell Movement
Cell Transformation, Neoplastic
Cricetinae
Cricetulus
Female
Fibronectins
Gene Amplification
Gene Expression
Genetic Vectors
Humans
Integrins
Macromolecular Substances
Ovary
Phenotype

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