Article
Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype.
Journal of virology - 1 Sept 1995
Delano M L, Brownstein D G
Abstract excerpt
Most inbred strains of mice, including DBA/2 (D2), are highly susceptible to the lethal effects of ectromelia virus, but C57BL/6 (B6) mice are innately resistant. Resistance is controlled by multiple, unlinked, autosomal dominant genes. Of 101 male (B6 x D2)F1 x D2 backcrossed (N2) mice, 18 died after ectromelia virus challenge and all were homozygous for the D2 allele at the proline-rich protein (Prp) locus on...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Disease Susceptibility
- Ectromelia, Infectious
- Female
- Genes, Dominant
- Genetic Linkage
- Genetic Predisposition to Disease
- Immunity, Innate