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Article

Prion protein genotypes of Italian sheep breeds with lysine-171 and phenylalanine-141 detection.

Veterinary microbiology - 28 May 2009

Pongolini Stefano, Bergamini Federica, Iori Alessandra, Migliore Sergio, Corradi Attilio, Bassi Stefano

Abstract excerpt

Amino acid polymorphisms of the prion protein gene influence sheep susceptibility to classical and atypical scrapie. Substitutions at codons 136, 154 and 171 play an important role in classical scrapie. Codon 141 leucine to phenylalanine mutation (AFRQ) has been recognized as an increased risk factor for atypical scrapie. In addition a rare allele with lysine at codon 171 (ARK) has been detected in Mediterranean...

Topics

Alleles
Amino Acid Sequence
Amino Acid Substitution
Animals
Genetic Predisposition to Disease
Genotype
Italy
Lysine
Phenylalanine
Prions
Scrapie

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sheep

Source

Identifiers

PMID: 19157728
DOI: 10.1016/j.vetmic.2008.12.012

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