Article
Characterization of PRNP and SPRN coding regions from atypical scrapie cases diagnosed in Poland.
Molecular biology reports - 1 Mar 2012
Piestrzyńska-Kajtoch Agata, Gurgul Artur, Polak Mirosław P, Smołucha Grzegorz, Zmudziński Jan F, Rejduch Barbara
Abstract excerpt
Scrapie, a fatal transmissible spongiform encephalopathy (TSE) occurs in two phenotypes: classical and atypical. Many authors point out that the polymorphism of three codons (136, 154, 171) of the PRNP (PrP gene) is associated with a sheep susceptibility to classical scrapie. Until now, only one PRNP gene variant coding phenylalanine at codon 141 has been found to be associated with atypical scrapie. Another...
Topics
- Animals
- Base Sequence
- DNA Primers
- GPI-Linked Proteins
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Molecular Sequence Data
- Nerve Tissue Proteins
- Poland