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Article

The association of a codon 136 PrP gene variant with the occurrence of natural scrapie.

Archives of virology - 1 Jan 1994

Hunter N, Goldmann W, Smith G, Hope J

Abstract excerpt

Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of...

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Identifiers

PMID: 7979991
DOI: 10.1007/BF01311184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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