Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The association of a codon 136 PrP gene variant with the occurrence of natural scrapie.

Archives of virology - 1 Jan 1994

Hunter N, Goldmann W, Smith G, Hope J

Abstract excerpt

Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of...

Topics

Alleles
Animals
Codon
Genetic Variation
Genotype
Polymorphism, Genetic
Prions
Reference Values
Scotland
Scrapie
Sheep

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7979991
DOI: 10.1007/BF01311184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7979991-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of a codon 136 PrP gene variant with the occurrence of natural scrapie.PMID 7979991Read ↗

Natural scrapie and PrP genotype: case-control studies in British sheep.Semantic proximity Read ↗

Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway.Semantic proximity Read ↗

Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie.Semantic proximity Read ↗

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Semantic proximity Read ↗

Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland.Semantic proximity Read ↗

PrP gene polymorphism and natural scrapie in Icelandic sheep.Semantic proximity Read ↗

PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie.Semantic proximity Read ↗

PrP genotyping of Austrian sheep breeds.Semantic proximity Read ↗

Prion protein allele A136 H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep.Semantic proximity Read ↗

Frequency of genotypes in the PrP prion protein gene locus in the Polish sheep population.Semantic proximity Read ↗

Allelic frequency and genotypes of prion protein at codon 136 and 171 in Iranian Ghezel sheep breeds.Semantic proximity Read ↗

Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.