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Article

Genetic and functional analysis of a set of HIV-1 envelope genes obtained from biological clones with varying syncytium-inducing capacities.

AIDS research and human retroviruses - 1 Oct 1992

Andeweg A C, Groenink M, Leeflang P, de Goede R E, Osterhaus A D, Tersmette M, Bosch M L

Abstract excerpt

To study HIV-1 envelope-mediated syncytium formation we have amplified, cloned, expressed, and sequenced individual envelope genes from a set of eight biological HIV-1 clones. These clones were obtained from two patients and display either a syncytium-inducing (SI) or nonsyncytium-inducing (NSI) phenotype. Upon expression through recombinant vaccinia virus, individual envelope gene products display heterogeneous...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Cytopathogenic Effect, Viral
DNA, Viral
Gene Expression
Gene Products, env
Genes, env
HIV-1
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Sequence Homology, Amino Acid

Viral Fusion Proteins

Source

Identifiers

PMID: 1457193
DOI: 10.1089/aid.1992.8.1803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1457193-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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