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Article

Genes that modify the hemochromatosis phenotype in mice.

The Journal of clinical investigation - 1 May 2000

Levy J E, Montross L K, Andrews N C

Abstract excerpt

Hereditary hemochromatosis (HH) is a prevalent human disease caused by a mutation in HFE, which encodes an atypical HLA class I protein involved in regulation of intestinal iron absorption. To gain insight into the pathogenesis of hemochromatosis, we have bred Hfe knockout mice to strains carryin...

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Topics

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Share to Iron, Dietary
Share to Receptors, Transferrin
Share to beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemochromatosis

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Source

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Identifiers

PMID: 10791995
DOI: 10.1172/JCI9635
PMCID: PMC315447

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10791995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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