Article
Angiotensinogen genotype, plasma protein and mRNA concentration in isolated systolic hypertension.
Clinical genetics - 1 May 2002
Davis D, Liyou N, Lockwood D, Johnson A
Abstract excerpt
Isolated systolic hypertension (ISH) occurs predominantly in the elderly, with a considerable morbidity and mortality. Its etiology is unknown but is likely to involve a significant genetic component. The aim of this study was to examine the angiotensinogen gene in ISH. The M235T and G(- 6)A polymorphisms were genotyped by polymerase chain reaction (PCR) in 86 ISH patients and 120 normotensive controls. Plasma...
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