Article
Angiotensin I-converting enzyme antisense gene therapy causes permanent antihypertensive effects in the SHR.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2000
Wang H, Reaves P Y, Gardon M L, Keene K, Goldberg D S, Gelband C H, Katovich M J, Raizada M K
Abstract excerpt
The renin-angiotensin system plays a critical role in the control of blood pressure (BP), and its hyperactivity is associated with the development and maintenance of hypertension. Although traditional pharmacological therapies targeted toward the inhibition of the renin-angiotensin system are effective in the control of this disease, they pose significant limitations. We used an antisense gene delivery strategy...
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