Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β

1 Feb 1996

Abstract excerpt

Previous studies have shown that transforming growth factor-beta (TGF-be ta) and tumor necrosis factor-alpha (TNF-alpha) modulate type I collagen gene expression in fibroblasts. To fine-map the corresponding response elements in the human alpha2(I) collagen (COL1A2) promoter, we have generated a series of 5' deletion promoter/chloramphenicol acetyltransferase (CAT) reporter gene constructs. Transient cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8621730
DOI: 10.1074/jbc.271.6.3272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-βPMID 8621730Read ↗

Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts.Semantic proximity Read ↗

Nuclear Factor-κB Mediates TNF-α Inhibitory Effect on α2(I) Collagen (COL1A2) Gene Transcription in Human Dermal FibroblastsSemantic proximity Read ↗

Transcription factor AP2 is required for expression of the rat transforming growth factor-alpha gene.Semantic proximity Read ↗

Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseasesSemantic proximity Read ↗

Regulation of type I collagen genes expressionSemantic proximity Read ↗

Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the alpha 2(I) collagen gene in human fibroblasts.Semantic proximity Read ↗

Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1 type I collagen geneSemantic proximity Read ↗

Cell-specific Induction of Distinct Oncogenes of the Jun Family Is Responsible for Differential Regulation of Collagenase Gene Expression by Transforming Growth Factor-β in Fibroblasts and KeratinocytesSemantic proximity Read ↗

Distinct involvement of the Jun‐N‐terminal kinase and NF‐κB pathways in the repression of the human COL1A2 gene by TNF‐αSemantic proximity Read ↗

Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin‐4: Analysis of the functional collagen promoter sequencesSemantic proximity Read ↗

Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.Semantic proximity Read ↗

Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.