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Article

Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells.

Experimental cell research - 1 Nov 2014

Genz Berit, Thomas Maria, Pützer Brigitte M, Siatkowski Marcin, Fuellen Georg, Vollmar Brigitte, Abshagen Kerstin

Abstract excerpt

Hepatic stellate cells (HSC) are well known initiators of hepatic fibrosis. After liver cell damage, HSC transdifferentiate into proliferative myofibroblasts, representing the major source of extracellular matrix in the fibrotic organ. Recent studies also demonstrate a role of HSC as progenitor or stem cell like cells in liver regeneration. Lhx2 is described as stem cell maintaining factor in different organs and...

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Identifiers

PMID: 24995995
DOI: 10.1016/j.yexcr.2014.06.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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