Article
Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor).
The Biochemical journal - 15 Apr 2000
Olsen J, Lefebvre O, Fritsch C, Troelsen J T, Orian-Rousseau V, Kedinger M, Simon-Assmann P
Abstract excerpt
Laminin-5 is a trimer of laminin alpha3, beta3 and gamma2 chains that is found in the intestinal basement membrane. Deposition of the laminin gamma2 chain at the basement membrane is of great interest because it undergoes a developmental shift in its cellular expression. Here we study the regulatory elements that control basal and cytokine-activated transcriptional expression of the LAMC2 gene, which encodes the...
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