Article

Transcriptional regulation of the COL1A2 gene in fibroblasts

2010-01-01

Abstract excerpt

Renal tubulointerstitial fibrosis is a major predictor of progressive glomerular disease. It occurs as a result of persistent inflammation and is characterised by excessive deposition of extracellular matrix (ECM) proteins, including accumulation of type I collagen, the most abundant protein of the ECM. Type I collagen is encoded by two genes, COL1A1 and COL1A2, that are tightly regulated at a transcriptional leve...

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Literature Corpus work: 63cf35a5-3781-54d2-9eb9-ce94ee3ca51a
DOI: 10.25560/5533

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