Article
Regulation of Type I Collagen Genes Expression
1 Jan 1995
Abstract excerpt
Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I collagen is a helerotrimer molecule consisting of two α1(I) chains and one α2(I) chain. The two...
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