Article
The promoter of the long variant of collagen XVIII, the precursor of endostatin, contains liver-specific regulatory elements.
Hepatology (Baltimore, Md.) - 1 Dec 2000
Liétard J, Théret N, Rehn M, Musso O, Dargère D, Pihlajaniemi T, Clément B
Abstract excerpt
The endostatin precursor collagen XVIII is expressed at high levels in human livers, the main source being hepatocytes. We have studied the regulatory elements in the promoter 2 of the Col18a1 gene that directs the transcription of the NC1-517 variant of collagen alpha1(XVIII), which is the main form expressed in the liver. The 5'-flanking region of Col18a1 gene was cloned, and a series of 5'-deletions from -3286...
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