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Article

The role of Hoxa-3 in mouse thymus and thyroid development.

Development (Cambridge, England) - 1 Jul 1995

Manley N R, Capecchi M R

Abstract excerpt

Targeted disruption of Hoxa-3 results in a number of regionally restricted defects in tissues and structures derived from or patterned by mesenchymal neural crest. However, analysis of mutant embryos with injections of a carbocyanine dye or with molecular markers that label these cells indicates that neither the amount nor the migration patterns of this neural crest population are grossly affected. Therefore, it...

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PMID: 7635047
DOI: 10.1242/dev.121.7.1989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The role of Hoxa-3 in mouse thymus and thyroid development.PMID 7635047Read ↗

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Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities.Semantic proximity Read ↗

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.Semantic proximity Read ↗

Lineage-specific responses to reduced embryonic Pax3 expression levels.Semantic proximity Read ↗

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Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.Semantic proximity Read ↗

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Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse.Semantic proximity Read ↗

Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesisSemantic proximity Read ↗

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