Article
Development of thyroid gland and ultimobranchial body cyst is independent of p63.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2011
Ozaki Takashi, Nagashima Kunio, Kusakabe Takashi, Kakudo Kennichi, Kimura Shioko
Abstract excerpt
The ultimobranchial body (UBB) and thyroid primordium are the origins of the thyroid gland that fuse around embryonic day 14.5 of mouse gestation, ultimately giving rise to calcitonin-producing C cells and thyroglobulin-producing follicular cells, respectively. A homeodomain transcription factor NKX2-1 is expressed both in the UBB and the thyroid primordium, and is critical for development of the thyroid gland....
Topics
- Animals
- Calcitonin
- Female
- Genotype
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microscopy, Electron
- Nuclear Proteins
- Phosphoproteins
- Thyroglobulin
- Thyroid Gland
- Thyroid Nuclear Factor 1