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Article

Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.

Development (Cambridge, England) - 1 Aug 2014

Reeh Kaitlin A G, Cardenas Kim T, Bain Virginia E, Liu Zhijie, Laurent Micheline, Manley Nancy R, Richie Ellen R

Abstract excerpt

The thymus and parathyroid glands arise from a shared endodermal primordium in the third pharyngeal pouch (3rd pp). Thymus fate is specified in the ventral 3rd pp between E9.5 and E11, whereas parathyroid fate is specified in the dorsal domain. The molecular mechanisms that specify fate and regulate thymus and parathyroid development are not fully delineated. Previous reports suggested that Tbx1 is required for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25053428
DOI: 10.1242/dev.111641
PMCID: PMC4197657

Genes

TEC
TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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