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Article

X chromosome choice occurs independently of asynchronous replication timing.

The Journal of cell biology - 31 Jan 2005

Gribnau Joost, Luikenhuis Sandra, Hochedlinger Konrad, Monkhorst Kim, Jaenisch Rudolf

Abstract excerpt

In mammals, dosage compensation is achieved by X chromosome inactivation in female cells. Xist is required and sufficient for X inactivation, and Xist gene deletions result in completely skewed X inactivation. In this work, we analyzed skewing of X inactivation in mice with an Xist deletion encompassing sequence 5 KB upstream of the promoter through exon 3. We found that this mutation results in primary nonrandom...

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Identifiers

PMID: 15668296
DOI: 10.1083/jcb.200405117
PMCID: PMC2171734

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