A rare leucine 40/arginine40 polymorphism on platelet glycoprotein IIIa is linked to the human platelet antigen 1b.

doi:10.1111/j.1423-0410.1994.tb01666.x

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Article

A rare leucine 40/arginine40 polymorphism on platelet glycoprotein IIIa is linked to the human platelet antigen 1b.

Vox sanguinis - 1 Jan 1994

Walchshofer S, Ghali D, Fink M, Panzer-Grümayer E R, Panzer S

Abstract excerpt

A rare polymorphism on glycoprotein (GP) IIIa is reported. Sequencing of a 482-base-pair (bp) PCR product of the genomic DNA of GPIIIa revealed a single-base exchange of a G<==>T polymorphism at base 12,569 that created an additional restriction site for MspI. This single-point mutation (frequenc...

Topics

Arginine
Base Sequence
Genetic Linkage
Humans
Infant, Newborn
Isoantigens
Leucine
Molecular Sequence Data
Mutation
Pedigree
Platelet Membrane Glycoproteins
Polymorphism, Restriction Fragment Length
Prospective Studies

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