Article
NH2-terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens.
The Journal of clinical investigation - 1 Feb 1992
Kuijpers R W, Faber N M, Cuypers H T, Ouwehand W H, von dem Borne A E
Abstract excerpt
The glycoprotein (GP) Ib/IX complex, a prominent platelet GP complex, is the primary receptor for vWF. Previously, we have established that an antigenic polymorphism of platelets, the HPA-2 or Ko alloantigen system, is located on the 45-kD amino-terminal globular domain of GPIb alpha. With the po...
Topics
- Base Sequence
- Blood Platelets
- Genotype
- Humans
- Isoantigens
- Methionine
- Molecular Sequence Data
- Phenotype
- Platelet Membrane Glycoproteins
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Threonine