Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.

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Article

Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.

Blood - 1 Jun 1992

Murata M, Furihata K, Ishida F, Russell S R, Ware J, Ruggeri Z M

Abstract excerpt

The platelet-specific alloantigen, Siba, located within the alpha-subunit of the glycoprotein (GP) Ib-IX membrane receptor, has been found to be involved in the pathogenesis of platelet transfusion refractoriness. We have identified the existence of a naturally occurring threonine/methionine dimorphism at position 145 of the GPIb alpha sequence, and determined that the Siba antigen corresponds to the molecule...

Topics

Amino Acids
Antigens
Antigens, Human Platelet
Base Sequence
Blood Component Transfusion
Blood Platelets
Codon
Gene Frequency
Genotype
Humans
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Platelet Membrane Glycoproteins

Polymerase Chain Reaction

Recombinant Proteins

Threonine

Transfection

Source

Open in PubMed

Identifiers

PMID: 1586750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1586750-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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