Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.

doi:10.1038/374159a0

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Article

Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.

Nature - 9 Mar 1995

Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Narumiya S, Kakizuka A

Abstract excerpt

Although pharmacological doses of retinoic acid (RA) have a wide variety of actions in vivo, experimental difficulties have prevented a definitive assignment of its physiological functions. We recently made a dominant-negative retinoic acid receptor (RAR) by a single amino-acid substitution which...

Topics

Animals
Embryonic and Fetal Development
Female
Genes, Dominant
Keratins
Mice
Mice, Transgenic
Mutation
Receptors, Retinoic Acid
Receptors, Thyroid Hormone
Skin
Skin Physiological Phenomena
Tretinoin

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