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Article

Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.

Nature - 9 Mar 1995

Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Narumiya S, Kakizuka A

Abstract excerpt

Although pharmacological doses of retinoic acid (RA) have a wide variety of actions in vivo, experimental difficulties have prevented a definitive assignment of its physiological functions. We recently made a dominant-negative retinoic acid receptor (RAR) by a single amino-acid substitution which creates a dominant-negative thyroid hormone receptor. The mutated RAR efficiently inhibited the endogenous activities...

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Source

Identifiers

PMID: 7533262
DOI: 10.1038/374159a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.PMID 7533262Read ↗

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