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Article

The vacuolating cytotoxin of <i>Helicobacter pylori</i>

1 Apr 1996

Abstract excerpt

Helicobacter pylori, the causative agent of chronic superficial gastritis and duodenal ulcer disease in humans, produces a unique cytotoxin (VacA) that induces cytoplasmic vacuolation in eukaryotic cells. The structural organization and processing of the vacuolating cytotoxin are characteristic of a family of proteins exemplified by Neisseria gonorrhoeae IgA protease. Although only 50% of H. pylori isolates...

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PMID: 8733223
DOI: 10.1111/j.1365-2958.1996.tb02612.x

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