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Article

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

The Journal of biological chemistry - 8 Apr 1994

Cover T L, Tummuru M K, Cao P, Thompson S A, Blaser M J

Abstract excerpt

Approximately 50% of Helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. Screening a lambda ZapII library of H. pylori 60190 chromosomal fragments permitted the identification of a 3864-base pair (bp) open reading frame (vacA) that encoded the vacuolating cytotoxin, and a > or = 567-bp upstream gene that was homologous to Escherichia coli cysteinyl-tRNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 8144644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.PMID 8144644Read ↗

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