Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

Article

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

The Journal of biological chemistry - 8 Apr 1994

Cover T L, Tummuru M K, Cao P, Thompson S A, Blaser M J

Abstract excerpt

Approximately 50% of Helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. Screening a lambda ZapII library of H. pylori 60190 chromosomal fragments permitted the identification of a 3864-base pair (bp) open reading frame (vacA) that encoded the v...

Topics

Amino Acid Sequence
Bacterial Proteins
Bacterial Toxins
Base Sequence
Cytotoxins
DNA, Bacterial
Genetic Variation
Helicobacter pylori
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid

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