Article
Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression.
Leukemia research - 1 Apr 1993
Gruber A, Briese B, Areström I, Vitols S, Björkholm M, Peterson C
Abstract excerpt
The purpose of the present study was to evaluate the distribution of the multiple drug resistance phenotype in leukemic cells with different levels of mdr1 gene expression. Peripheral leukemic cells from 8 patients (5 with detectable and 3 with undetectable mdr1 RNA levels) were incubated with daunorubicin (1 microM) in the absence and presence of verapamil (6.6 microM). Daunorubicin accumulation in individual...
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