Anthracycline subcellular distribution in human leukemic cells by microspectrofluorometry: factors contributing to drug-induced cell death and reversal of multidrug resistance.

doi:10.1038/sj.leu.2400668

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Article

Anthracycline subcellular distribution in human leukemic cells by microspectrofluorometry: factors contributing to drug-induced cell death and reversal of multidrug resistance.

Leukemia - 1 Jul 1997

Morjani H, Millot J M, Belhoussine R, Sebille S, Manfait M

Abstract excerpt

There is a large discrepancy between the changes in drug accumulation and the changes in drug cytotoxicity that accompany development of anthracycline in multidrug-resistant cells. Moreover, although different molecular targets for anthracyclines such as DNA, cell membranes, or enzymes like topoi...

Topics

Antibiotics, Antineoplastic
Cell Death
Doxorubicin
Drug Resistance, Multiple
Humans
Leukemia
Phenotype
Spectrometry, Fluorescence

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