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Article

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth.

Nature reviews. Molecular cell biology - 1 Mar 2014

Edgar Bruce A, Zielke Norman, Gutierrez Crisanto

Abstract excerpt

In endoreplication cell cycles, known as endocycles, cells successively replicate their genomes without segregating chromosomes during mitosis and thereby become polyploid. Such cycles, for which there are many variants, are widespread in protozoa, plants and animals. Endocycling cells can achieve ploidies of >200,000 C (chromatin-value); this increase in genomic DNA content allows a higher genomic output, which...

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PMID: 24556841
DOI: 10.1038/nrm3756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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