Article
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.
Biochemical and biophysical research communications - 26 Jul 1995
Kuo M L, Yang N C
Abstract excerpt
Apigenin, a plant flavonoid, induced the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at a quite low concentration of 12.5 microM. In the present study, we have examined the components of this Ras-mediated signaling transduction to determine whether they were involved in the apigenin-induced reversion process. Interestingly, the consitutively activated mitogen activated protein kinase...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Chamomile
- Flavonoids
- Genes, fos
- Genes, jun
- Genes, ras
- Mice
- Oils, Volatile