Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.

doi:10.1242/dev.120.3.695

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Article

Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.

Development (Cambridge, England) - 1 Mar 1994

Millen K J, Wurst W, Herrup K, Joyner A L

Abstract excerpt

The cerebellum is an ideal system to study pattern formation in the central nervous system because of its simple cytoarchitecture and regular organization of folds and neural circuitry. Engrailed-2 (En-2) is expressed in a spatially restricted broad band around the mesencephalic-metencephalic jun...

Topics

Animals
Blotting, Southern
Cerebellum
Exons
Genes
Genes, Homeobox
Immunohistochemistry
Lac Operon
Mice
Mice, Mutant Strains
Morphogenesis
Phenotype

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