Article
Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.
Science (New York, N.Y.) - 8 Mar 1991
Joyner A L, Herrup K, Auerbach B A, Davis C A, Rossant J
Abstract excerpt
The two mouse genes, En-1 and En-2, that are homologs of the Drosophila segmentation gene engrailed, show overlapping spatially restricted patterns of expression in the neural tube during embryogenesis, suggestive of a role in regional specification. Mice homozygous for a targeted mutation that d...
Topics
- Animals
- Blastocyst
- Cell Line
- Cerebellum
- Chimera
- Chromosome Deletion
- Female
- Genes, Homeobox
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Nervous System