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Article

Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.

Science (New York, N.Y.) - 8 Mar 1991

Joyner A L, Herrup K, Auerbach B A, Davis C A, Rossant J

Abstract excerpt

The two mouse genes, En-1 and En-2, that are homologs of the Drosophila segmentation gene engrailed, show overlapping spatially restricted patterns of expression in the neural tube during embryogenesis, suggestive of a role in regional specification. Mice homozygous for a targeted mutation that deletes the homeobox were viable and showed no obvious defects in embryonic development. This may be due to functional...

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Identifiers

PMID: 1672471
DOI: 10.1126/science.1672471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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