Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemimelic extra-toes (Hx) on chromosome 5.

doi:10.1016/0888-7543(90)90570-k

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Article

Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemimelic extra-toes (Hx) on chromosome 5.

Genomics - 1 Feb 1990

Martin G R, Richman M, Reinsch S, Nadeau J H, Joyner A

Abstract excerpt

The mouse genome contains two genes, En-1 and En-2, with sequence similarity to the engrailed gene of Drosophila. Using conventional linkage crosses, we have shown that En-1 maps approximately 0.28 cM distal to the dominant hemimelia (Dh) gene on chromosome 1 and that En-2 maps approximately 1.1...

Topics

Animals
Blotting, Northern
Chromosome Mapping
Chromosomes
Crosses, Genetic
Female
Genes
Genetic Linkage
Male
Mice
Mutation
Phenotype
Recombination, Genetic
Transcription, Genetic

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