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Article

Factors in the genetic background suppress the engrailed-1 cerebellar phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2003

Bilovocky Natalie A, Romito-DiGiacomo Rita R, Murcia Crystal L, Maricich Stephen M, Herrup Karl

Abstract excerpt

The mouse homeodomain protein, Engrailed-1, is generally viewed as an essential player in the early establishment and maintenance of the midbrain/hindbrain region that gives rise to the cerebellum and midbrain. In keeping with this, engineered null mutations at this locus have been reported to lead to perinatal lethality accompanied by near-total absence of cerebellar and caudal midbrain structures. We report...

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Share to Limb Deformities, Congenital

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Source

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Identifiers

PMID: 12832534
PMCID: PMC6741147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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