Article
Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.
Oncogene - 23 Sept 1999
Ruas M, Brookes S, McDonald N Q, Peters G
Abstract excerpt
Inherited mutations in the CDKN2A/INK4a/MTS1 tumour suppressor gene on chromosome 9p21 are associated with familial predisposition to melanoma and other tumour types. Nonsense and missense mutations are also found in a variety of sporadic cancers, and over 140 sequence variants have already been recorded in the literature. In assessing the relevance of these variants and for counselling members of affected...
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