Article
CDKN2A mutations in multiple primary melanomas.
The New England journal of medicine - 26 Mar 1998
Monzon J, Liu L, Brill H, Goldstein A M, Tucker M A, From L, McLaughlin J, Hogg D, Lassam N J
Abstract excerpt
BACKGROUND: Germ-line mutations in the CDKN2A tumor-suppressor gene (also known as p16, p16INK4a, and MTS1) have been linked to the development of melanoma in some families with inherited melanoma. Whether mutations in CDKN2A confer a predisposition to sporadic (nonfamilial) melanoma is not known. In some patients with sporadic melanoma, one or more additional primary lesions develop, suggesting that some of...
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