Article
Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53 mutation and identifies a tumour suppressor gene locus at 5q13.1-21.
British journal of cancer - 1 Jul 1996
Tavassoli M, Steingrimsdottir H, Pierce E, Jiang X, Alagoz M, Farzaneh F, Campbell I G
Abstract excerpt
Forty-nine ovarian tumours were examined for loss of heterozygosity (LOH) on chromosome 5 using eight microsatellite markers spanning both arms, including one at the APC locus. LOH on 5q was a frequent event, detectable in 23 of 49 (47%) tumours, whereas 5p LOH was detected in only 1 of 22 tumour...
Topics
- Base Sequence
- Chromosomes, Human, Pair 5
- DNA, Neoplasm
- DNA, Satellite
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Staging
- Ovarian Neoplasms
- Polymorphism, Genetic