Article
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair.
Molecular and cellular biology - 1 Aug 1995
Ayyagari R, Impellizzeri K J, Yoder B L, Gary S L, Burgers P M
Abstract excerpt
The saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA), encoded by the POL30 gene, is essential for DNA replication and DNA repair processes. Twenty-one site-directed mutations were constructed in the POL30 gene, each mutation changing two adjacently located charged amino acids to...
Topics
- Cell Cycle Proteins
- Cell Division
- Cold Temperature
- DNA Damage
- DNA Mutational Analysis
- DNA Polymerase II
- DNA Polymerase III
- DNA Repair
- DNA Replication
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Genes, Dominant
- Homeodomain Proteins
- Minor Histocompatibility Antigens