A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.

doi:10.1093/genetics/151.2.511

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Article

A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.

Genetics - 1 Feb 1999

Kokoska R J, Stefanovic L, Buermeyer A B, Liskay R M, Petes T D

Abstract excerpt

The POL30 gene of the yeast Saccharomyces cerevisiae encodes the proliferating cell nuclear antigen (PCNA), a protein required for processive DNA synthesis by DNA polymerase delta and epsilon. We examined the effects of the pol30-52 mutation on the stability of microsatellite (1- to 8-bp repeat u...

Topics

Cell Cycle
DNA Repair
DNA, Fungal
DNA, Satellite
Genes, Fungal
Mutation
Proliferating Cell Nuclear Antigen
Saccharomyces cerevisiae

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