Article
A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.
Genetics - 1 Feb 1999
Kokoska R J, Stefanovic L, Buermeyer A B, Liskay R M, Petes T D
Abstract excerpt
The POL30 gene of the yeast Saccharomyces cerevisiae encodes the proliferating cell nuclear antigen (PCNA), a protein required for processive DNA synthesis by DNA polymerase delta and epsilon. We examined the effects of the pol30-52 mutation on the stability of microsatellite (1- to 8-bp repeat units) and minisatellite (20-bp repeat units) DNA sequences. It had previously been shown that this mutation...
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