Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins.

doi:10.1128/mcb.14.7.4390-4397.1994

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Article

Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins.

Molecular and cellular biology - 1 Jul 1994

McAlear M A, Howell E A, Espenshade K K, Holm C

Abstract excerpt

In addition to its role as a processivity factor in DNA replication, proliferating cell nuclear antigen (PCNA) may function in the regulation of cell cycle progression. We present genetic evidence that PCNA interacts with the gene product of CDC44, an essential nucleotide-binding protein that enc...

Topics

Alleles
Amino Acid Sequence
Animals
Antibodies
Carrier Proteins
Cloning, Molecular
DNA Polymerase III
DNA Replication
Escherichia coli
Humans
Hyaluronan Receptors
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Proliferating Cell Nuclear Antigen

Protein Conformation

Protein Structure, Secondary

Source

Open in PubMed Open full text

Identifiers

PMID: 7516465
DOI: 10.1128/mcb.14.7.4390-4397.1994
PMCID: PMC358810

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7516465-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins.PMID 7516465Read ↗

A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair.Semantic proximity Read ↗

In vivo analysis reveals that the interdomain region of the yeast proliferating cell nuclear antigen is important for DNA replication and DNA repair.Semantic proximity Read ↗

Schizosaccharomyces pombe replication and repair proteins: proliferating cell nuclear antigen (PCNA).Semantic proximity Read ↗

Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants.Semantic proximity Read ↗

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.Semantic proximity Read ↗

Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.Semantic proximity Read ↗

Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon.Semantic proximity Read ↗

C-terminal flap endonuclease (rad27) mutations: lethal interactions with a DNA ligase I mutation (cdc9-p) and suppression by proliferating cell nuclear antigen (POL30) in Saccharomyces cerevisiae.Semantic proximity Read ↗

The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis.Semantic proximity Read ↗

The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding.Semantic proximity Read ↗

CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C.Semantic proximity Read ↗

Something's gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes.Semantic proximity Read ↗

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