Article
Schizosaccharomyces pombe proliferating cell nuclear antigen mutations affect DNA polymerase delta processivity.
The Journal of biological chemistry - 5 Jul 1996
Arroyo M P, Downey K M, So A G, Wang T S
Abstract excerpt
We introduced nine site-directed mutations into seven conserved fission yeast proliferative cell nuclear antigen (PCNA) residues, Leu2, Asp63, Arg64, Gly69, Gln201, Glu259, and Glu260, either as single or as double mutants. Both the recombinant wild type and mutant PCNAs were able to form homotri...
Topics
- Adenosine Triphosphatases
- Alleles
- Amino Acid Sequence
- Animals
- Cattle
- Chromatography, Gel
- Conserved Sequence
- DNA Polymerase III
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Genes, Fungal
- Genotype
- Homeodomain Proteins
- Kinetics
- Macromolecular Substances
- Minor Histocompatibility Antigens
- Models, Structural
- Mutagenesis, Site-Directed