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Article

Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.

Molecular & general genetics : MGG - 1 Mar 1998

Arroyo M P, Wang T S

Abstract excerpt

Twenty-eight site-directed mutations were introduced into the fission yeast gene (pcn1+) that encodes proliferating cell nuclear antigen (PCNA) and their in vivo effects analyzed in a strain with a null pcn1 background. Mutants defective in enhancing processivity of DNA polymerase delta have previously been identified. In this study, we assessed all of the mutants for their sensitivities to temperature,...

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Source

Identifiers

PMID: 9563836
DOI: 10.1007/s004380050676

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.PMID 9563836Read ↗

Schizosaccharomyces pombe replication and repair proteins: proliferating cell nuclear antigen (PCNA).Semantic proximity Read ↗

Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants.Semantic proximity Read ↗

A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair.Semantic proximity Read ↗

Schizosaccharomyces pombe proliferating cell nuclear antigen mutations affect DNA polymerase delta processivity.Semantic proximity Read ↗

Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins.Semantic proximity Read ↗

Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.Semantic proximity Read ↗

In vivo analysis reveals that the interdomain region of the yeast proliferating cell nuclear antigen is important for DNA replication and DNA repair.Semantic proximity Read ↗

Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.Semantic proximity Read ↗

Mutual correction of faulty PCNA subunits in temperature-sensitive lethal mus209 mutants of Drosophila melanogaster.Semantic proximity Read ↗

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.Semantic proximity Read ↗

The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis.Semantic proximity Read ↗

Two modes of FEN1 binding to PCNA regulated by DNA.Semantic proximity Read ↗

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