Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.

doi:10.1007/s004380050676

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Article

Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.

Molecular & general genetics : MGG - 1 Mar 1998

Arroyo M P, Wang T S

Abstract excerpt

Twenty-eight site-directed mutations were introduced into the fission yeast gene (pcn1+) that encodes proliferating cell nuclear antigen (PCNA) and their in vivo effects analyzed in a strain with a null pcn1 background. Mutants defective in enhancing processivity of DNA polymerase delta have prev...

Topics

Alleles
Cell Cycle
DNA Damage
DNA Repair
DNA Replication
Gamma Rays
Genes, Fungal
Genes, cdc
Hydroxyurea
Methyl Methanesulfonate
Mutagenesis, Site-Directed
Phenotype
Proliferating Cell Nuclear Antigen
Saccharomyces
Temperature
Ultraviolet Rays

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