Article
Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon.
Molecular and cellular biology - 1 Nov 1997
Eissenberg J C, Ayyagari R, Gomes X V, Burgers P M
Abstract excerpt
The importance of the interdomain connector loop and of the carboxy-terminal domain of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) for functional interaction with DNA polymerases delta (Poldelta) and epsilon (Pol epsilon) was investigated by site-directed mutagenesis. Two a...
Topics
- Binding Sites
- DNA Mutational Analysis
- DNA Polymerase II
- DNA Polymerase III
- DNA Replication
- Endodeoxyribonucleases
- Escherichia coli
- Flap Endonucleases
- Genes, Fungal
- Models, Molecular
- Mutagenesis
- Nucleic Acid Conformation
- Phenotype
- Proliferating Cell Nuclear Antigen
- Protein Binding
- Recombinant Proteins
- Saccharomyces cerevisiae