Article
Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor.
The Journal of biological chemistry - 14 Jul 1995
Sealfon S C, Chi L, Ebersole B J, Rodic V, Zhang D, Ballesteros J A, Weinstein H
Abstract excerpt
A conserved helix 2 Asp is required for the proper function of many G-protein-coupled receptors. To reveal the structural basis for the role of this residue, the additive effects of mutations at this locus and at a conserved helix 7 locus were investigated in the 5-HT2A receptor. All mutant receptors studied retained high affinity agonist and antagonist binding. Whereas an Asp-->Asn mutation in helix 2 eliminated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.